Grade 2 (partial perfusion): The contrast material passes across the obstruction and opacifies the coronary bed distal to the obstruction.Grade 1 (penetration without perfusion): The contrast material passes beyond the area of obstruction but “hangs up” and fails to opacify the entire coronary bed distal to the obstruction for the duration of the cine-angiographic filming sequence.Grade 0 (no perfusion): There is no antegrade flow beyond the point of occlusion.Images were evaluated at the clinical site and later at a central radiographic lab to further ensure consistency. In 1985, due to statistically significant differences in recanalization rates with tPA over streptokinase, phase 1 of the study was stopped. TIMI grade flow 0 represented total occlusion, and TIMI grade flow 3 represented normal epicardial perfusion. Phase 1 studied IV streptokinase and IV tPA (tissue plasminogen activator) and assessed "recanalization of the totally occluded artery 90 minutes after the start of drug infusion." For this study, the TIMI Coronary Grade Flow was established to ensure a uniform and consistent method of recording epicardial perfusion on coronary arteriography. In 1983, the TIMI (Thrombolysis in Myocardial Infarction) study group (Brigham and Women's Hospital, Boston, Massachusetts) chose to conduct a randomized, double-blind, multicenter study to assess the efficacy of intravenous (IV) streptokinase. Initial therapeutic reperfusion was established using intravenous and intracoronary thrombolytic agents, and several studies were conducted on them. In an attempt to intervene, physicians in the 1970s studied ligation of canine coronary arteries and documented prevention of necrosis with ligation release under appropriate time limits. It has been widely accepted that it is due to the insufficient blood supply to the cardiac tissue. TIMI 2 flow (partial reperfusion) is delayed or sluggish antegrade flow with complete filling of the distal territory.Acute myocardial infarction (MI) is the leading cause of death worldwide.TIMI 1 flow (penetration without perfusion) is faint antegrade coronary flow beyond the occlusion, with incomplete filling of the distal coronary bed.TIMI 0 flow (no perfusion) refers to the absence of any antegrade flow beyond a coronary occlusion.'TIMI Grade Flow' is a scoring system from 0-3 referring to levels of coronary blood flow assessed during percutaneous coronary angioplasty: TIMI risk can be calculated on the TIMI website under "Clinical Calculators." 'TIMI risk' estimates mortality following acute coronary syndromes. % risk at 14 days of: all-cause mortality, new or recurrent MI, or severe recurrent ischemia requiring urgent revascularization. ST changes of at least 0.5mm on admission EKG At least 2 angina episodes within the last 24hrs Or female first-degree relative or mother less than 65). (CAD in male first-degree relative, or father less than 55, Such as: Hypertension -> 140/90 or on antihypertensives, Known Coronary Artery Disease (CAD) (coronary stenosis >= 50%) Aspirin use in the last 7 days (patient experiences chest pain despite ASA use in past 7days) TIMI Score Calculation (1 point for each): It is used to categorize a patient's risk of death and ischemic events and provides a basis for therapeutic decision making. The TIMI Risk Score is used in patients with U nstable Angina / Non-ST Elevation Myocardial Infarction. It has conducted numerous practice-changing clinical trials in patients with cardiovascular disease or risk factors for cardiovascular disease TIMI stands for ' Thrombolysis In Myocardial Infarction' and is the name of an Academic Research Organization (ARO) which was founded by Dr.
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